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Received by NCI from Jackson Laboratory in 2002. Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains. In response to challenge, 129S1/SvImJ mice develop immune-mediated nephritis characterized by proteinuria, glomerulonephritis and tubulointerstitial disease (Xie et al., 2004). Most recently 129 mice are a widely used strain in the production of targeted mutations due to the availability of several lines of embryonic stem cells.
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