Science at the Frederick National Lab
With our partners, we are developing faster and less expensive ways of turning laboratory discoveries into new diagnostic tests and treatments for cancer and AIDS.
Featured This Month:
Puri and Blumenthal Develop Portable Device to Test for HIV-1
Anu Puri, Ph.D., and Robert Blumenthal, Ph.D., are developing a portable device
for use in the field to test for AIDS. This device is a small, handheld electrochemical
nanobiosensor unit equipped with a gold nanolayered, nanoporous membrane. The unit
will run primarily on batteries, and researchers will detect the presence of HIV-1
in patient blood samples by reading the machine’s analysis on a meter. “It’s a quick,
cost-effective, and user-friendly way to screen pathogens and will be a novel use
of nanobiosensors,” Puri said.
Read the full article in The Poster
NCI-Frederick has about 3,000 government and contractor employees with a wide range
of expertise in basic, translational, and preclinical research and development in
cancer and AIDS.
Read about some of our recent research advances.
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Selected Platinum Publications
Cell and Tumor Biology
Gabriely G, Yi M, Narayan RS, Niers JM, Wurdinger T, Imitola J, Ligon KL,
Kesari S, Esau C, Stephens RM, Tannous BA, Krichevsky AM. Human Glioma Growth Is Controlled by MicroRNA-10b. Cancer
Res 2011.
Clinical Trials and Observations
Kuhns DB, Alvord WG, Heller T, Feld JJ, Pike KM, Marciano BE, Uzel G, DeRavin
SS, Priel DA, Soule BP, Zarember KA, Malech HL, Holland SM, Gallin JI.
Residual
NADPH Oxidase And Survival In Chronic Granulomatous Disease. N Engl J Med363(27):2600-10,
2010.
Genes Structure and Regulation
Jain S, Tillinger A, Mopidevi B, Pandey VG, Chauhan CK, Fiering SN, Warming
S, Kumar A.
Transgenic Mice with -6A Haplotype of the Human Angiotensinogen Gene Have Increased
Blood Pressure Compared with -6G Haplotype. J Biol Chem 285(52):41172-41186,
2010.